Digoxin interstage mortality

Author: aqul

August undefined, 2024

WebDec 1, 2024 · The impact of digoxin on interstage mortality remains unproven. Abstract. The use of Digoxin has been associated with improved interstage survival following … WebInterstage mortality was 9.4%. Digoxin use was associated with lower risk of death (P =.03) on univariable analysis, however no single medication was an independent predictor on regression analysis. Change in weight-for-age z-score was studied as outcome of somatic growth with 36.3% patients showing a decrease during the interstage period.

Development of a validated risk score for interstage death or ...

WebMar 18, 2024 · Digoxin is used for the treatment of heart failure in pediatric patients and acts by controlling numerous functions of the cardiovascular system. Digoxin use in single ventricle congenital heart disease may decrease interstage mortality. The study will be conducted in approximately 48 subjects at approximately 13 investigational centers. line drawings to colour in

Trends in Discharge Prescription of Digoxin After Norwood …

WebMay 4, 2024 · Conclusions This systematic review and meta-analysis suggests that digoxin significantly decreases interstage period mortality with a concurrent significant decrease in weight for age. The odds of arrhythmia or other complications are not significantly different with digoxin based on current data. Competing Interest Statement. The authors have ... WebJan 11, 2016 · Interstage mortality by surgical site (n=50 centers). This figure shows interstage mortality (IM) among the 544 infants in the … WebQuality improvement efforts have focused on reducing interstage mortality for infants with hypoplastic left heart syndrome (HLHS). In 1/2016, two publications reported that use of digoxin was associated with reduced interstage mortality. The degree to which these findings have affected real world practice has not been evaluated. line drawings to color

Kaplan–Meier survival curves for the no digoxin and digoxin …

WebIn the digoxin group, there was a trend toward a decrease in the risk of death attributed to worsening heart failure (risk ratio, 0.88; 95 percent confidence interval, 0.77 to 1.01; P = 0.06 ... WebJan 11, 2016 · typical mortality rates of 15% to 20% occurring around the stage 1 palliation (S1P), and interstage mortality (IM) rates of 10% to 15% in survivors discharged to … line drawing sunflowerWebApr 11, 2024 · cardiac function , digoxin , echocardiogram , interstage mortality , interstage period , single-ventricle congenital heart disease Search for Similar Articles … hot springs in northern utah

"WebMar 1, 2024 · Background Infants born with single right ventricle congenital heart disease (SVCHD) physiology, such as hypoplastic left heart syndrome and variants, are at a high risk for death or transplant during the interstage (IS) defined as the period between Stage 1 surgery (aorto-pulmonary shunt with arch reconstruction) and Stage 2 surgery (superior … " - Digoxin interstage mortality

Digoxin interstage mortality

Development of a Validated Risk Score for Interstage Death or ...

WebJan 26, 2016 · Interstage mortality for those not on digoxin was 12.3%, compared to 2.9% among those on digoxin, with an adjusted hazard ratio of 3.5 (95% CI, 1.1–11.7; … WebJan 13, 2016 · Background: Mortality for infants with single ventricle congenital heart disease remains as high as 8% to 12% during the interstage period, the time between …

Did you know?

WebSep 1, 2024 · The use of digoxin has been associated with significantly lower interstage mortality (ISM) following stage 1 palliation (S1P) of single ventricle heart disease. 1, 2 Two separate studies demonstrated this association near simultaneously using data from the National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) registry … WebJan 13, 2016 · Interstage mortality for those not on digoxin was 12.3%, compared to 2.9% among those on digoxin, with an adjusted hazard ratio of 3.5 (95% CI, 1.1–11.7; P=0.04). The number needed to treat to prevent 1 death was 11 patients. There were no differences in complications between the 2 groups during the interstage period.

WebFeb 23, 2024 · Digoxin use at the time of discharge was the preeminent protective feature against home interstage mortality both by univariate analysis and advanced ML. The protective effect of digoxin for interstage mortality, despite an unclear therapeutic mechanism, has been reported in several studies [ 9 , 17 , 32 ]. WebOct 1, 2024 · Interstage mortality is poorly understood and remains a high-risk period for patients with SVCHD. We present a validated risk score to predict interstage mortality that identified moderate or greater TR and a persistent supplemental O 2 requirement as the greatest risk subgroup. Interstage mortality may be impacted by intensifying …

WebNov 16, 2012 · Interstage mortality for those not on digoxin was 12.3%, compared to 2.9% among those on digoxin, with an adjusted hazard ratio of 3.5 (95% CI, 1.1–11.7; P=0.04). The number needed to treat to ... WebNational Center for Biotechnology Information

WebOct 20, 2024 · Digoxin has been associated with reduced interstage mortality for patients with functional single ventricles with aortic hypoplasia or ductal-dependent systemic circulation. The NEONATE (type of stage …

WebJan 1, 2016 · Digoxin use in infants with single ventricle congenital heart disease is associated with significantly reduced interstage mortality, and the number needed to treat to prevent 1 death was 11 patients. Background Mortality for infants with single ventricle congenital heart disease remains as high as 8% to 12% during the interstage period, the … hot springs in north queenslandWebQuality improvement efforts have focused on reducing interstage mortality for infants with hypoplastic left heart syndrome (HLHS). In 1/2016, two publications reported that use of digoxin was associated with reduced interstage mortality. The degree to which these findings have affected real world pr … hot springs in north idahoWebResearch Explained: Digoxin Use Is Associated With Reduced Interstage Mortality in Patients With No History of Arrhythmia After Stage I Palliation for Single Ventricle Heart Disease. Interstage mortality (IM) remains significant after stage 1 palliation (S1P) for single-ventricle heart disease (SVD), with many deaths sudden and unexpected. line drawing tea potWebSerum digoxin concentration (SDC) data were infrequently considered, but available data suggested a greater association between increasing SDC and all-cause mortality. This … line drawings to watercolorWebFeb 20, 1997 · Background: The role of cardiac glycosides in treating patients with chronic heart failure and normal sinus rhythm remains controversial. We studied the effect of … line drawing techniques ethicsWebNov 1, 2024 · Interstage mortality for those not on digoxin was 12.3%, compared to 2.9% among those on digoxin, with an adjusted hazard ratio of 3.5 (95% CI, 1.1–11.7; P=0.04). The number needed to treat to ... hot springs inn thermopolis wyWebMar 6, 2024 · Patients with a serum digoxin concentration ≥1.2 ng/ml had a 56% increased hazard of mortality (adjusted HR, 1.56; 95% confidence interval [CI], 1.20–2.04). When analyzed as a continuous variable, serum digoxin concentration was associated with a 19% higher adjusted hazard of death for each 0.5 ng/ml increase (p = 0.0010); these results ... line drawing template