Hepg2 sorafenib ic50

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August undefined, 2024

Web3 nov. 2015 · Conversely, sorafenib is not active against a number of kinases including ERK-1, MEK-1, EGFR, HER-2/neu, IGFR-1, c-met, c-yes, PKB, PKA, CDK1/cyclin B, … Web【摘要】：背景与目的:在肝癌(HCC)的临床治疗中,一线药物索拉非尼(Sorafenib)在治疗过程中已出现获得性耐药(acquired resistance/adaptive resistance),目前尚无解决办法。本研 …

索拉菲尼获得性耐药肝癌细胞株的建立及其生物学特性--《第二十 …

Web11 jan. 2024 · The IC50 values of Sorafenib under normoxia and hypoxia were tested ( Figure 2 A). In HepG2 cells, the IC50 was 12.8 μM under normoxia and 194.2 μM under … WebThe IC 50 of the parental and LR cells were also determined (Figure 1B ). In the resistant cells, the IC 50 of lenvatinib showed a higher concentration compared to parental cells (Figure 1B ). Accordingly, lenvatinib treatment had no influence on the growth of individual clones of resistant cells compared to their parental cells (Figure 1C,D ). coworker leaving funny

Molecular mechanisms of sorafenib action in liver cancer cells

Web23 sep. 2024 · Our findings revealed that the miR-15a-5p deficiency abrogated the IC50 of SOR, and the IC50 reduction was restored by the si-IGF1 incorporation into SR-Huh7 … WebSORAFENIB (recombinant); Clinically useful anticancer agent; Initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine … Web1 okt. 2024 · After 24 h, the sorafenib concentration that inhibition activity reached about 50% (IC50) was determined using the CCK8 assay. Then, the cells were treated with … disney godmother funny

Sorafenib induces autophagic cell death and apoptosis in …

MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular …

http://activeinhibitor.com/yzj/919.html WebBiological Activity. Description. Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell … disney golden collection nftWeb10 jan. 2011 · Sorafenib, a VEGFR inhibitor with activity against RAF kinase, is active against hepatocellular carcinoma (HCC); however, the possible involvement of sorafenib in the EMT remains unclear. Here, we examined the effect of sorafenib on the EMT. coworker leaving for another job

"Web9 jul. 2024 · The IC50 concentrations of DOX and SORA used in this experiment for HepG2 and SK-HEP-1 cell lines are kept constant for all the experiments until specifically … " - Hepg2 sorafenib ic50

Hepg2 sorafenib ic50

Web1 jan. 2024 · IC 50 value represents the concentration of a compound where 50% of its maximal inhibitory effect is observed, and it is commonly used as a measure of drug's … Web30 apr. 2024 · The half-maximal inhibitory concentrations (IC50) of HepG2-SR and SNU449-SR cells to sorafenib were 2–3 times higher than that of the parental cells at 17.09 and …

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http://acikerisim.omu.edu.tr/xmlui/handle/20.500.12712/33943 WebSorafenib (BAY 43-9006, NSC-724772) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib inhibits VEGFR-2, …

Web方法:首先通过药物敏感性实验CCK8法测定索拉菲尼对HepG2细胞和7721细胞对索拉非尼的半数抑制浓度IC50值(约5μM左右)。然后将长至对数生长期的HepG2细胞和SMMC-7721细胞以每孔7.5×104个细胞接种在6孔板中,24h后予以低于IC50的浓度(1μM)开始刺激,2天换液一次,继续以含1μM索拉非尼的培养基培养。 1-2周后,收集6孔板中残存的细胞,胰酶消化,重新 … Web15 sep. 2024 · Cell lines, chemicals and antibodies. Human HCC HepG2 cell line was obtained from American Type Culture Collection (ATCC, Rockville, MD, USA). Sorafenib-resistant cell line, HepG2 R, was induced by continuous treatment of HepG2 cells with sorafenib up to 10 μmol/L to imitate acquired resistance.Both cell lines were cultured in …

Web生物活性. Sorafenib tosylate (BAY 43-9006 tosylate,NSC-724772 tosylate) is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, … Web7 mei 2024 · Sorafenib and Regorafenib are the recommended first- and second-line therapies in patients with advanced hepatocellular carcinoma (HCC). Lenvatinib and …

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Web21 sep. 2024 · Sorafenib, an orally available kinase inhibitor, is the standard first-line systemic drug for advanced hepatocellular carcinoma (HCC), and it exerts potent … coworker leaving gifWeb26 mrt. 2015 · Sorafenib treatment decreased the number of viable cells in all 12 thyroid carcinoma cell lines analyzed, and efficiency of sorafenib did not span a large range, … disney golden ears club disney gold editionWebSupplementary Fig. S1 Induction of sorafenib resistance by YB -1 in hepatocarcinoma cell lines. (A) The IC50 values of sorafenib were detected by CCK-8 assays in four HCC cell … coworker leaving good luckWeb11 jan. 2024 · In the HepG2 xenograft model, Sorafenib inhibited tumor growth significantly, while Nec weakened the effect ( Figure S3D,E ). All the results showed that Sorafenib induced hepatocellular carcinoma death partly via the necroptosis pathway in vivo and in vitro. 2.2. Hypoxia Contributed to HCC Resistance to Sorafenib disney goldfish crosswordWebThe designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 μM in comparison to sorafenib (IC50 … disney golden books illustrationsWeb2 aug. 2024 · Cell viability assay was utilized to detected the 50% inhibitory concentration (IC50) of sorafenib in Hep3B-SR, HepG2-SR and their parental counterparts. Resistant … coworker leaving meme sad