Web4. júl 2024 · Contraindications Valproic acid is contraindicated in patients with hepatic disorders, significant hepatic impairment, hypersensitivity to components of the drug and class of drug, urea cycle disorders, mitochondrial disorders, or suspected disorders in patients <2-year-old, and pregnancy (for migraine headache prophylaxis use of valproic … Web21. mar 2024 · 4 CONTRAINDICATIONS DILANTIN is contraindicated in patients with: A history of hypersensitivity to phenytoin, its inactive ingredients, or other hydantoins [see Warnings and Precautions (5.5)]. Reactions have ... 5 WARNINGS AND PRECAUTIONS
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Web8. dec 2015 · Interactions. Phenytoin is an inducer of the hepatic cytochrome P450 microsomal isoenzymes CYP3A4, CYP2D6, CYP1A2, CYP2C9 and CYP2C19. Phenytoin is metabolised primarily by. CYP2C9 (major) and CYP2C19 (minor), thus several drugs may inhibit or induce the. metabolism of phenytoin. WebPatients were categorized by degree of sodium nadir: normal, mild, moderate, or severe, and analyzed by levetiracetam versus phenytoin. Patients were matched 2:1 regarding age … stillwater medical center infusion clinic
Contraindications for phenytoin sodium oral - WebMD
Web15. jan 2024 · Phenytoin is a voltage-gated, sodium channel blocker, stabilizing the inactive state of the sodium channel and prolonging the neuronal refractory period. Phenytoin acts on the sodium channels on both neuronal and cardiac tissue. Web17. feb 2024 · Contraindications Hypersensitivity to phenytoin, other hydantoins, or any component of the formulation; concurrent use of delavirdine; history of prior acute … Web2. dec 2024 · Phenytoin is highly protein bound and extensively metabolised by the liver. Reduce dosage to prevent accumulation and toxicity in patients with impaired liver function. Where protein binding levels are reduced, total serum … stillwater medical center human resources