Ptf1a 性分化

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August undefined, 2024

WebMar 21, 2024 · GeneCards Summary for PTF1A Gene. PTF1A (Pancreas Associated Transcription Factor 1a) is a Protein Coding gene. Diseases associated with PTF1A …

Foxp- and Skor-family proteins control differentiation of Purkinje ...

WebOct 25, 2024 · To elucidate the effects of Ptf1a homozygous loss, we prepared Elastase-CreERTM; Ptf1afloxed/floxed mice and found that homozygous Ptf1a deletion in adult … WebJul 7, 2015 · The protein PTF1A is crucial for establishing the differentiation state of acinar cells. In the most common form of pancreatic cancer, acinar cells are reprogrammed to … docker container terminal how to use

Induced PTF1a expression in pancreatic ductal adenocarcinoma …

WebPTF1A effects growth and lineage specification of pancreatic multipotent progenitor cells during development. This strain has been replaced by a C57BL/6J congenic version as Stock No. 036577 . 019378 STOCK Ptf1a tm2(cre/ESR1)Cvw /J The Ptf1a Cre-ERTM knock-in allele was designed to both abolish pancreas specific transcription factor, 1a ( Ptf1a ... Web分かれる．Pdx1陽性，Ptf1a陽性かつcMyc高発現Cpa1陽性の多分化能を持った前駆細胞が分裂を繰り返して分枝が生じ始め，前駆細胞は旺盛な増殖を示して分枝のtipを形成す … WebOct 29, 2024 · PTF1A, a crucial TF for exocrine pancreas development, is detected in early pancreatic progenitors giving rise to endocrine and exocrine fates . Nkx6.1-deficient … docker containers vs kubernetes containers

ptf1a+, ela3l− cells are developmentally maintained progenitors …

WebJun 14, 2024 · Background Notch/Hes1 signaling has been shown to play a role in determining the fate of pancreatic progenitor cells. However, its function in postnatal pancreatic maturation is not fully elucidated. Methods We generated conditional Hes1 knockout and/or Notch intracellular domain (NICD) overexpression mice in Ptf1a- or Pdx1 … WebThese antibodies target PTF1A in Human, Rat and Mouse samples. Our PTF1A polyclonal, monoclonal, recombinant monoclonal and recombinant polyclonal antibodies are developed in Rabbit, Mouse and Goat. Find the PTF1A antibody that fits your needs. Choose from 1 of 15 PTF1A antibodies, which have been validated in experiments with 27 images ... docker container terminologyWebNov 15, 2006 · The vertebrate neural retina comprises six classes of neurons and one class of glial cells, all derived from a population of multipotent progenitors. There is little information on the molecular mechanisms governing the specification of cell type identity from multipotent progenitors in the developing retina. We report that Ptf1a, a basic-helix … docker container sync time with host

"WebMar 1, 2024 · We find that the proportion of ptf1a +, ela3l − cells decreases with age, whereas the total number appears to be unaffected by age and even by repeated acinar ablation. This highlights ptf1a +, ela3l − cells as a maintained cell population of the pancreas. Currently, we can only speculate about the molecular and cellular mechanism ... " - Ptf1a 性分化

Ptf1a 性分化

Anti-PTF1A Antibodies Invitrogen - Thermo Fisher Scientific

WebAs predicted, PTF1a induced gene expression of digestive enzymes and acinar-specific transcription factors, while MIST1 induced gene expression of vesicle trafficking molecules as well as activation of unfolded protein response components, all of which are essential to handle the high protein production load that is characteristic of acinar cells. WebMice deficient in forebrain Ptf1a exhibit abnormal sex-biased behaviors and maldevelopment of sexual dimorphism in the brain and reproductive organs. Loss of …

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WebJan 15, 2024 · Retinas from Ptf1a heterozygous embryos had a strong signal for miR-181a at the inner edge of the neuroblast layer and in a few scattered cells in the neuroblast layer, which overlapped with AP2α ... WebNov 23, 2024 · The transcription factor Ptf1a is a crucial helix–loop–helix (bHLH) protein selectively expressed in the pancreas, retina, spinal cord, brain, and enteric nervous …

WebJul 3, 2024 · We show that conditional Ptf1a-deficient mice (Ptf1a cKO) exhibit abnormalities in sex-biased behaviors and reproductive organs in both sexes. Gonadal … 本グループは、以前からPtf1a遺伝子が胎児期マウスの視床下部で発現することを見出していましたが（参考文献1）、本研究ではその発現についてさらに詳細に調べました。すると臨界期よりかなり前の発達段階で、視床下部の、特に脳室に面した神経前駆細胞でPtf1aが発現することを見出しました。その発現は胎 … See more 脳の性分化に関わる遺伝子はこれまでにもいくつか同定されてきましたが、発現時期と発現細胞の種類から、Ptf1aはそれらの中でも最も早く働く最上流遺伝子と言えます。今回の研究から … See more 本研究成果は、以下の事業・研究領域・研究課題によって得られました。 1. 文部科学省科学研究費補助金新学術領域研究「個性創発脳」(16H06528、17H05963)、基盤研 … See more Forebrain Ptf1a is required for sexual differentiation of the brain. Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, … See more

WebFeb 21, 2013 · Despite continued interest over several decades, Sd resisted efforts to identify the causal gene—until now. In this issue of PLOS Genetics, three laboratories independently identify the Sd mutation as an 8.5 kb ETn retrotransposon insertion 12.3 kb upstream from the Ptf1a gene –. Ptf1a encodes a cell type–restricted basic helix-loop … WebMar 21, 2024 · ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression. ptf1a functions as a "pancreatic …

Web图 2 Tamoxifen 诱导后，Ptf1a CreERT2/+; Rosa26 tdTomato/+ 小鼠各组织中tdTomato的表达情况。. CreERT2重组酶的活性特异表达在胰腺腺泡，有少量细胞漏表达；在小脑、垂体和胃粘膜下层有极少量细胞表达。. 未检测到表达的组织包括：胸腺、心脏、肺、肝、睾丸、肾 …

WebMar 15, 2007 · Basic helix-loop-helix (bHLH) transcription factors are important regulators of retinal neurogenesis. In the developing retina, proneural bHLH genes have highly defined expressions, which are influenced by pattern formation and cell-specification pathways. We report here that the tissue-specific bHLH transcription factor Ptf1a (also known as PTF1 … docker container through vpnWebPancreatic cancer arises from mutations in exocrine acinar cells. Krah et al. demonstrate that preserving acinar cell identity protects these cells from oncogenic Kras-induced tumorigenesis. Furthermore, re-expressing the acinar differentiation gene Ptf1a in existing precancerous lesions in vivo, or human pancreatic cancer cells in vitro, induces … docker container time out of syncWebJun 14, 2024 · Signaling pathways involved in vertebrate pancreas patterning and specification. Fgf10 is important for the proliferation of pancreatic progenitor cells [[]] and interacts with both Wnt and Shh signaling, establishing a cross-regulation by feedback loops [[]].Wnt signaling has been observed to promote pancreatic fate, by expression of … docker container too many open filesWebOct 25, 2024 · PTF1A positivity per lineage-labeled acinar cells was 74.0 ± 6.9% in control mice and 4.4 ± 2.8% in Ptf1a cKO mice on day 3, and 84.2 ± 1.8% in control mice and 1.9 ± 0.4% in Ptf1a cKO mice on ... docker container timezone changeWebJul 3, 2024 · A Machinery whereby Hypothalamic Ptf1a Regulates Sexual Differentiation of the Brain. As described above, brain feminization does not automatically occur by non … docker container to host networkWebtPSA是指血清中的总PSA (total PSA)，就是血液中所有PSA的含量，所以也作为主要的判断依据。. 目前国内外比较一致的观点是: 当tPSA>4.0 ng/ml. 即认为出现异常。. 但如果是初 … docker container user passwordWeb1. Abnormal neurogenesis of the cerebellar VZ, e.g., mutations in the PTF1A gene, which is a known regulator of the VZ and which can lead to cerebellar agenesis (Hoshino, 2006).. 2. Abnormal neurogenesis of the rhombic limb, e.g., patients with mutations of the FOXC1 gene, a regulator for growth factors and other signaling molecules for neurogenesis of the … docker container utf-8